Arsenal will assess right-back Hector Bellerin, who is back in training after recovering from an ankle injury.
Francis Coquelin returns after serving a one-game European ban but Mathieu Debuchy, Per Mertesacker, Danny Welbeck and Santi Cazorla remain injured.
Stoke defender Bruno Martins Indi is available despite being caught by an opponent’s elbow last weekend.
However, fellow centre-back Ryan Shawcross is again set to miss out with a calf problem.
Geoff Cameron is still sidelined by a knee problem, but Marko Arnautovic is fit despite suffering a knock against Burnley.
John Motson: “What a week so far for Arsenal! Five goals at West Ham and another four in Basel to top their Champions League group for the first time since 2011.
“Arsenal are well placed in the league – will they push on and show us they are the real deal, or flounder and reveal familiar fragilities?
“They have a fantastic home record against Stoke but the much-improved Potters will be no pushover.
“Mark Hughes’ men have lost just one of their last nine and have not conceded more than one goal in any of those games.
“The recent switch to 3-4-3 suits talented pair Marko Arnautovic and Xherdan Shaqiri, who will be very dangerous if Stoke are given chances on the counter-attack.”
Arsenal manager Arsene Wenger on his side’s development:“We have a good team dynamic, we have a very strong team spirit and we have more maturity, definitely. Unfortunately, the teams around us have more as well.
“You can assess the Premier League as very open and very interesting… December is a very important month and for us even more because we have some big games.
“Stoke is another challenge for us [to show] that we can reset, refocus and continue our development and take the points.”
Stoke manager Mark Hughes: “In the past as a club we’ve struggled to get results at places like Old Trafford and Stamford Bridge but we’ve been able to do that in recent times.
“This is the only one left standing so it would be great to get it out of the way. Our recent form is good and we’re in good heart so confidence is high, that is huge in football, so we’ll be able to benefit from that.
“It’s up to us to restrict them to minimal chances and make sure we’re creating chances when going the other way.”
Stoke are on a decent run and have got themselves in a really comfortable position in the top half of the table.
I don’t see them causing Arsenal too many problems at Emirates Stadium, though, and I think Alexis Sanchez will find a way through – again.
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.
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