Manchester United top scorer Zlatan Ibrahimovic will be assessed, having missed the EFL Cup semi-final first-leg victory over Hull because of illness.
Marcos Rojo could also be back, but fellow defender Eric Bailly is at the Africa Cup of Nations.
Liverpool’s Philippe Coutinho is expected to make his first league appearance since November after an ankle injury.
Jordan Henderson and Joel Matip are back in training and could feature.
Sadio Mane is away on Africa Cup of Nations duty.
Steve Wilson: “It’s unlikely that Jose Mourinho’s call for more noise at Old Trafford will go ignored – when Liverpool arrive at Old Trafford an old-fashioned atmosphere is guaranteed.
“The intense rivalry between the two cities, which arguably has its roots in the difficult birth of the Manchester Ship Canal, has been embodied in culture, music and -most tangibly of all – in football for over a century.
“It’s a fixture that can become the stuff of folklore. Score a dramatic winner and your name might be consecrated in terrace songs for decades.
“Enter that arch-Scouser and enemy of Anfield, Wayne Rooney. The one-time Croxteth kid stands poised to outscore the revered Knight of the Realm and King of Old Trafford, Bobby Charlton. What better opposition? What better script?
“If Mourinho picks him…”
Manchester United manager Jose Mourinho on opposite number Jurgen Klopp: “I just think we like to win. Everyone has his own personality, style and coaching and leading.
“Probably we have some similarities and other characteristics that make us different. He wants to play the game as much as I want, I am not sure if he is so calm as I am. It is one more big match.”
Liverpool manager Jurgen Klopp: “I hear it in your questions, I hear it when I talk to different people, because of our last game (the 1-0 defeat at Southampton) it is like ‘Oh my God – and now it is Man United’ but give me 11 players and we will be competitive.
“I know how they (players) react to not-that-good performances. It is not about being confident before the game, it is about getting confidence in the game with the right kind of movements, right kind of defending.”
Manchester United got a 0-0 draw at Anfield in October in a game that was basically a Jose Mourinho masterpiece. His gameplan was to restrict Liverpool to relatively few chances, and it worked.
United will be far more ambitious in attack at Old Trafford, however, and Liverpool boss Jurgen Klopp has some big decisions to make over the fitness of some of his players.
This is a massive game for both teams and I think it will end up with a point apiece.
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.
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