West Ham captain Mark Noble will be assessed after he took a blow to his knee against Leicester.
Alvaro Arbeloa, Arthur Masuaku, Diafra Sakho and Gokhan Tore remain out.
Manchester United are without defender Eric Bailly, who is now on international duty with the Ivory Coast at the Africa Cup of Nations.
Manager Jose Mourinho says Michael Carrick and Wayne Rooney have a chance of being involved after missing the New Year’s Eve win over Middlesbrough.
Rooney has been out with a thigh problem, while Carrick has been ill.
Jonathan Pearce: “I was lucky enough to be commentating alongside Sir Trevor Brooking for West Ham’s thrilling Upton Park finale win over Manchester United.
“Since then the Hammers have been looking to christen their new home with a famous victory. This could be the day.
“All the pointers suggest an away win. Manchester United have only lost once in their last 16 league meetings.
“Mourinho has been beaten once in 12 games against West Ham. Wayne Rooney has scored 11 against them. Anthony Martial five in five meetings.
“But it’s time Andy Carroll broke his duck against the visitors. A shock? Maybe!”
Manchester United manager Jose Mourinho: “It’s difficult for us and difficult for West Ham. We’ve both played at the same time, we’ve both had difficult matches and couldn’t rest players.
“The intensity of the game was very high for them, for sure, against Leicester, and for us the same. And now we have 48 hours to play, so it’s difficult for all of us.”
West Ham United
SAM (Sports Analytics Machine) is a super-computer created by @ProfIanMcHale at the University of Salford that is used to predict the outcome of football matches.
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